| 4. Ronde | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 5. Ronde | 01.07.2021 | Atenas | - | Defensor Sporting | 2:0 | ||||
| 7. Ronde | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
| 8. Ronde | 22.07.2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
| 9. Ronde | 28.07.2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | ||||
| 10. Ronde | 05.08.2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Ronde | 14.08.2021 | Danubio | - | Defensor Sporting | 0:1 |  |
|||
| 12. Ronde | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 13. Ronde | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Ronde | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Ronde | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 |
Uruguay
Italië