| 3. Ronde | 06.02.2022 | Vida | - | Marathón | 3:0 | ||||
| 6. Ronde | 20.02.2022 | Vida | - | Honduras Progreso | 0:2 | ||||
| 7. Ronde | 27.02.2022 | Victoria | - | Vida | 1:2 | ||||
| 8. Ronde | 03.03.2022 | Vida | - | Real Sociedad | 4:0 | ||||
| 9. Ronde | 06.03.2022 | Vida | - | Real España | 0:1 | ||||
| 10. Ronde | 13.03.2022 | Marathón | - | Vida | 1:1 | ||||
| 11. Ronde | 20.03.2022 | Vida | - | Motagua | 2:0 | ||||
| 12. Ronde | 04.04.2022 | Olimpia | - | Vida | 2:0 | ||||
| 13. Ronde | 07.04.2022 | Vida | - | Platense | 1:1 | ||||
| 14. Ronde | 10.04.2022 | Honduras Progreso | - | Vida | 3:1 |  |
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| 15. Ronde | 15.04.2022 | Real Sociedad | - | Vida | 4:1 | ||||
| 17. Ronde | 24.04.2022 | Vida | - | Victoria | 1:1 | ||||
| 18. Ronde | 01.05.2022 | Real España | - | Vida | 1:4 |
Honduras