| 1. Ronde | 25.07.2021 | Independiente del Valle | - | Orense SC | 3:2 |  |
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| 3. Ronde | 08.08.2021 | Aucas | - | Orense SC | 0:0 | ||||
| 4. Ronde | 15.08.2021 | Orense SC | - | Barcelona | 1:0 | ||||
| 5. Ronde | 22.08.2021 | Orense SC | - | Deportivo Cuenca | 1:1 | ||||
| 6. Ronde | 29.08.2021 | Manta | - | Orense SC | 0:0 | ||||
| 7. Ronde | 18.09.2021 | Orense SC | - | Guayaquil City | 2:0 | |
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| 8. Ronde | 25.09.2021 | Mushuc Runa | - | Orense SC | 0:0 | ||||
| 9. Ronde | 02.10.2021 | Orense SC | - | Macará | 2:1 |  |
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| 12. Ronde | 30.10.2021 | Orense SC | - | Técnico Universitario | 0:0 | ||||
| 13. Ronde | 06.11.2021 | Universidad Catolica | - | Orense SC | 1:0 | ||||
| 14. Ronde | 21.11.2021 | Orense SC | - | LDU Quito | 1:1 | ||||
| 15. Ronde | 28.11.2021 | Olmedo | - | Orense SC | 0:2 |
Ecuador