| 1. Ronde | 25.07.2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 2. Ronde | 30.07.2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 | ||||
| 3. Ronde | 06.08.2021 | Metalist 1925 Kharkiv | - | Chernomorets Odessa | 3:2 | ||||
| 4. Ronde | 13.08.2021 | Shakhtar Donetsk | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 5. Ronde | 20.08.2021 | Vorskla Poltava | - | Metalist 1925 Kharkiv | 2:0 |  |
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| 6. Ronde | 28.08.2021 | Metalist 1925 Kharkiv | - | SK Dnipro-1 | 1:2 | |
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| 7. Ronde | 11.09.2021 | Metalist 1925 Kharkiv | - | Dinamo Kiev | 0:2 | |
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| 8. Ronde | 19.09.2021 | FK Lviv | - | Metalist 1925 Kharkiv | 0:0 | ||||
| 9. Ronde | 26.09.2021 | Desna Chernigov | - | Metalist 1925 Kharkiv | 1:2 | |
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| 11. Ronde | 16.10.2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | |
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| 12. Ronde | 22.10.2021 | Metalist 1925 Kharkiv | - | Inhulets Petrove | 4:0 | ||||
| 13. Ronde | 31.10.2021 | Metalist 1925 Kharkiv | - | Zorya Lugansk | 1:6 | ||||
| 14. Ronde | 05.11.2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 | |
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| 15. Ronde | 22.11.2021 | NK Veres | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 18. Ronde | 12.12.2021 | Chernomorets Odessa | - | Metalist 1925 Kharkiv | 2:1 |
Brazilië