| 3. Ronde | 29.08.2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 | ||||
| 9. Ronde | 22.10.2021 | Royal Excel Mouscron | - | RWD Molenbeek | 1:1 | ||||
| 11. Ronde | 06.11.2021 | Royal Excel Mouscron | - | SK Deinze | 2:0 | ||||
| 14. Ronde | 05.12.2021 | KVC Westerlo | - | Royal Excel Mouscron | 4:3 | ||||
| 18. Ronde | 30.01.2022 | RWD Molenbeek | - | Royal Excel Mouscron | 2:0 |  |
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| 19. Ronde | 05.02.2022 | Royal Excel Mouscron | - | Waasland-Beveren | 3:0 | ||||
| 20. Ronde | 12.02.2022 | KVC Westerlo | - | Royal Excel Mouscron | 1:0 | ||||
| 23. Ronde | 06.03.2022 | Royal Excel Mouscron | - | RWD Molenbeek | 0:1 | ||||
| 24. Ronde | 13.03.2022 | Lierse Kempenzonen | - | Royal Excel Mouscron | 0:1 | ||||
| 25. Ronde | 18.03.2022 | Royal Excel Mouscron | - | SK Deinze | 1:2 | |
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| 26. Ronde | 03.04.2022 | Excelsior Virton | - | Royal Excel Mouscron | 2:0 | |
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