| 1. Ronde | 16.07.2022 | Tacuary | - | Guaireña FC | 0:0 |  |
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| 4. Ronde | 31.07.2022 | Tacuary | - | Club Olimpia | 2:1 | ||||
| 5. Ronde | 06.08.2022 | General Caballero DJLM | - | Tacuary | 0:4 |  |
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| 6. Ronde | 16.08.2022 | Tacuary | - | Resistencia SC | 1:1 | ||||
| 7. Ronde | 21.08.2022 | 12 de Octubre de Itauguá | - | Tacuary | 0:2 | |
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| 8. Ronde | 29.08.2022 | Tacuary | - | Sol de América | 1:0 | ||||
| 9. Ronde | 04.09.2022 | Club Nacional | - | Tacuary | 1:0 | ||||
| 10. Ronde | 11.09.2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Ronde | 14.09.2022 | Libertad | - | Tacuary | 2:0 | ||||
| 13. Ronde | 26.09.2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 14. Ronde | 02.10.2022 | Tacuary | - | Sportivo Ameliano | 1:1 | ||||
| 15. Ronde | 06.10.2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 16. Ronde | 12.10.2022 | Tacuary | - | General Caballero DJLM | 0:3 | ||||
| 17. Ronde | 15.10.2022 | Resistencia SC | - | Tacuary | 0:3 | ||||
| 18. Ronde | 22.10.2022 | Tacuary | - | 12 de Octubre de Itauguá | 5:1 | |
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| 19. Ronde | 26.10.2022 | Sol de América | - | Tacuary | 2:2 | ||||
| 20. Ronde | 31.10.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 21. Ronde | 06.11.2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Ronde | 12.11.2022 | Tacuary | - | Libertad | 1:0 |  |
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Paraguay