| 2. Ronde | 09.08.2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
| 3. Ronde | 15.08.2021 | UNAN Managua | - | ART Municipal Jalapa | 1:0 | ||||
| 4. Ronde | 22.08.2021 | ART Municipal Jalapa | - | CD Walter Ferretti | 2:0 | ||||
| 5. Ronde | 30.08.2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 | ||||
| 6. Ronde | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 7. Ronde | 12.09.2021 | Real Madriz | - | ART Municipal Jalapa | 1:0 |  |
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| 8. Ronde | 20.09.2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 10. Ronde | 03.10.2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 0:0 | ||||
| 13. Ronde | 21.10.2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 | ||||
| 14. Ronde | 24.10.2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | ||||
| 15. Ronde | 01.11.2021 | ART Municipal Jalapa | - | Real Madriz | 0:1 | |
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| 16. Ronde | 04.11.2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 17. Ronde | 19.11.2021 | ART Municipal Jalapa | - | Juventus Managua | 1:1 | ||||
| 18. Ronde | 22.11.2021 | Diriangén FC | - | ART Municipal Jalapa | 5:0 |
Nicaragua