| 3. Ronde | 06.08.2018 | Santos Laguna | - | Puebla FC | 2:0 | ||||
| 4. Ronde | 13.08.2018 | Deportivo Guadalajara | - | Santos Laguna | 1:2 |  |
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| 5. Ronde | 20.08.2018 | Santos Laguna | - | UANL Tigres | 3:1 |  |
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| 6. Ronde | 23.08.2018 | Club Tijuana | - | Santos Laguna | 2:2 | ||||
| 7. Ronde | 27.08.2018 | Santos Laguna | - | Cruz Azul | 1:1 | ||||
| 8. Ronde | 02.09.2018 | Deportivo Toluca | - | Santos Laguna | 2:1 | |
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| 9. Ronde | 16.09.2018 | Santos Laguna | - | Club León | 3:0 | ||||
| 10. Ronde | 24.09.2018 | Santos Laguna | - | CD Veracruz | 1:1 | ||||
| 11. Ronde | 30.09.2018 | Club Necaxa | - | Santos Laguna | 0:1 | ||||
| 12. Ronde | 06.10.2018 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
| 13. Ronde | 21.10.2018 | CF Pachuca | - | Santos Laguna | 1:1 | ||||
| 14. Ronde | 27.10.2018 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 15. Ronde | 04.11.2018 | Gallos Blancos | - | Santos Laguna | 2:1 | |
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| 16. Ronde | 12.11.2018 | Santos Laguna | - | CF América | 1:1 | ||||
| 17. Ronde | 25.11.2018 | Pumas UNAM | - | Santos Laguna | 1:1 |
Brazilië
Mexico