| 1. Ronde | 21.08.2021 | Empoli FC | - | Lazio | 1:3 | ||||
| 2. Ronde | 28.08.2021 | Juventus | - | Empoli FC | 0:1 | ||||
| 3. Ronde | 11.09.2021 | Empoli FC | - | Venezia FC | 1:2 |  |
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| 4. Ronde | 19.09.2021 | Empoli FC | - | Sampdoria | 0:3 | ||||
| 5. Ronde | 22.09.2021 | Cagliari Calcio | - | Empoli FC | 0:2 | ||||
| 7. Ronde | 03.10.2021 | AS Roma | - | Empoli FC | 2:0 | |
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| 8. Ronde | 17.10.2021 | Empoli FC | - | Atalanta | 1:4 | ||||
| 9. Ronde | 23.10.2021 | US Salernitana 1919 | - | Empoli FC | 2:4 | |
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| 10. Ronde | 27.10.2021 | Empoli FC | - | Inter | 0:2 | ||||
| 11. Ronde | 31.10.2021 | Sassuolo Calcio | - | Empoli FC | 1:2 | ||||
| 12. Ronde | 05.11.2021 | Empoli FC | - | Genoa CFC | 2:2 | ||||
| 13. Ronde | 22.11.2021 | Hellas Verona | - | Empoli FC | 2:1 | ||||
| 14. Ronde | 27.11.2021 | Empoli FC | - | ACF Fiorentina | 2:1 | ||||
| 15. Ronde | 02.12.2021 | Torino FC | - | Empoli FC | 2:2 | ||||
| 16. Ronde | 06.12.2021 | Empoli FC | - | Udinese Calcio | 3:1 | ||||
| 17. Ronde | 12.12.2021 | SSC Napoli | - | Empoli FC | 0:1 |
Zwitserland