| 1. Ronde | 17.10.2020 | Sporting Gijón B | - | Cultural Leonesa | 2:4 | ||||
| 2. Ronde | 25.10.2020 | Cultural Leonesa | - | CD Numancia | 0:0 | ||||
| 3. Ronde | 01.11.2020 | CD Lealtad | - | Cultural Leonesa | 1:0 | ||||
| 5. Ronde | 21.11.2020 | Real Valladolid B | - | Cultural Leonesa | 1:1 |  |
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| 6. Ronde | 29.11.2020 | Cultural Leonesa | - | Burgos CF | 1:1 |  |
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| 7. Ronde | 06.12.2020 | UP Langreo | - | Cultural Leonesa | 2:2 | |
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| 8. Ronde | 12.12.2020 | Cultural Leonesa | - | CD Covadonga | 2:0 | ||||
| 9. Ronde | 09.01.2021 | Marino de Luanco | - | Cultural Leonesa | 0:2 | ||||
| 12. Ronde | 31.01.2021 | Cultural Leonesa | - | CD Lealtad | 0:0 | |
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| 13. Ronde | 06.02.2021 | Real Oviedo B | - | Cultural Leonesa | 1:3 | ||||
| 10. Ronde | 10.02.2021 | Cultural Leonesa | - | Sporting Gijón B | 1:1 | ||||
| 14. Ronde | 14.02.2021 | Cultural Leonesa | - | Real Valladolid B | 1:1 | ||||
| 15. Ronde | 20.02.2021 | Burgos CF | - | Cultural Leonesa | 2:1 | ||||
| 11. Ronde | 24.02.2021 | CD Numancia | - | Cultural Leonesa | 0:2 | ||||
| 16. Ronde | 06.03.2021 | Cultural Leonesa | - | UP Langreo | 3:1 | ||||
| 17. Ronde | 14.03.2021 | CD Covadonga | - | Cultural Leonesa | 1:0 | ||||
| 18. Ronde | 21.03.2021 | Cultural Leonesa | - | Marino de Luanco | 2:0 |
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