| 1. Ronde | 23.07.2021 | FK Lviv | - | FK Mariupol | 1:1 |  |
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| 2. Ronde | 01.08.2021 | FK Mariupol | - | Desna Chernigov | 1:2 | ||||
| 3. Ronde | 07.08.2021 | SK Dnipro-1 | - | FK Mariupol | 2:1 | ||||
| 4. Ronde | 16.08.2021 | FK Mariupol | - | Chernomorets Odessa | 2:3 | ||||
| 5. Ronde | 22.08.2021 | FK Mariupol | - | Zorya Lugansk | 3:4 | ||||
| 8. Ronde | 18.09.2021 | FK Mariupol | - | Shakhtar Donetsk | 0:5 | |
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| 15. Ronde | 21.11.2021 | Vorskla Poltava | - | FK Mariupol | 5:1 | |
Oekraïne