| 1. Ronde | 13.01.2022 | Municipal Pérez Zeledón | - | Municipal Grecia | 1:1 |  |
|||
| 2. Ronde | 16.01.2022 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 6. Ronde | 13.02.2022 | Santos de Guápiles | - | Municipal Pérez Zeledón | 0:1 | ||||
| 7. Ronde | 20.02.2022 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 0:0 | ||||
| 9. Ronde | 03.03.2022 | Municipal Pérez Zeledón | - | Guadalupe | 0:1 | ||||
| 13. Ronde | 11.04.2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 3:0 | ||||
| 14. Ronde | 14.04.2022 | Municipal Pérez Zeledón | - | AD San Carlos | 1:0 | ||||
| 15. Ronde | 20.04.2022 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:1 | ||||
| 16. Ronde | 24.04.2022 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:2 | ||||
| 17. Ronde | 27.04.2022 | Municipal Pérez Zeledón | - | Santos de Guápiles | 1:1 | ||||
| 18. Ronde | 02.05.2022 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 2:1 | ||||
| 19. Ronde | 05.05.2022 | Municipal Pérez Zeledón | - | Sporting FC | 0:1 | ||||
| 20. Ronde | 08.05.2022 | Guadalupe | - | Municipal Pérez Zeledón | 2:2 | |
|||
| 21. Ronde | 11.05.2022 | Jicaral | - | Municipal Pérez Zeledón | 2:1 |
Costa Rica