| 4. Ronde | 11.09.2021 | Southampton FC [U18] | - | Arsenal FC [U18] | 3:3 |  |
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| 6. Ronde | 02.10.2021 | Southampton FC [U18] | - | Leicester City [U18] | 0:3 | ||||
| 7. Ronde | 23.10.2021 | West Bromwich Albion [U18] | - | Southampton FC [U18] | 1:5 | ||||
| 9. Ronde | 06.11.2021 | Southampton FC [U18] | - | Aston Villa [U18] | 6:3 | ||||
| 10. Ronde | 20.11.2021 | Tottenham Hotspur [U18] | - | Southampton FC [U18] | 0:3 | ||||
| 14. Ronde | 15.01.2022 | Southampton FC [U18] | - | Tottenham Hotspur [U18] | 1:2 | |
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| 15. Ronde | 22.01.2022 | Brighton & Hove Albion [U18] | - | Southampton FC [U18] | 3:4 | ||||
| 20. Ronde | 12.03.2022 | Birmingham City [U18] | - | Southampton FC [U18] | 1:4 | |
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| 22. Ronde | 02.04.2022 | Arsenal FC [U18] | - | Southampton FC [U18] | 4:2 |
Engeland