| 1. Ronde | 24.07.2021 | FC Hradec Králové | - | Bohemians Praha 1905 | 1:1 | ||||
| 2. Ronde | 01.08.2021 | Bohemians Praha 1905 | - | Viktoria Plzeň | 1:2 |  |
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| 3. Ronde | 08.08.2021 | FK Jablonec | - | Bohemians Praha 1905 | 2:2 | |
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| 4. Ronde | 14.08.2021 | Bohemians Praha 1905 | - | Sparta Praag | 1:1 | ||||
| 5. Ronde | 21.08.2021 | FK Pardubice | - | Bohemians Praha 1905 | 3:0 | ||||
| 6. Ronde | 29.08.2021 | Bohemians Praha 1905 | - | FK Teplice | 4:2 | ||||
| 7. Ronde | 11.09.2021 | FC Fastav Zlín | - | Bohemians Praha 1905 | 1:3 | ||||
| 8. Ronde | 19.09.2021 | Bohemians Praha 1905 | - | Slavia Praag | 1:5 | ||||
| 9. Ronde | 25.09.2021 | Baník Ostrava | - | Bohemians Praha 1905 | 4:1 | ||||
| 10. Ronde | 02.10.2021 | Bohemians Praha 1905 | - | Sigma Olomouc | 2:0 | ||||
| 11. Ronde | 16.10.2021 | FK Mladá Boleslav | - | Bohemians Praha 1905 | 4:1 | |
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| 12. Ronde | 23.10.2021 | 1. FC Slovácko | - | Bohemians Praha 1905 | 1:0 | ||||
| 14. Ronde | 06.11.2021 | Slovan Liberec | - | Bohemians Praha 1905 | 2:1 | |
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| 16. Ronde | 27.11.2021 | Viktoria Plzeň | - | Bohemians Praha 1905 | 6:0 | ||||
| 13. Ronde | 01.12.2021 | Bohemians Praha 1905 | - | MFK Karviná | 3:0 | ||||
| 17. Ronde | 05.12.2021 | Bohemians Praha 1905 | - | FK Jablonec | 1:2 |
Rusland