| 2. Ronde | 19.09.2021 | Wuppertaler SV [A-jun] | - | Fortuna Köln [A-jun] | 2:1 | ||||
| 3. Ronde | 25.09.2021 | Fortuna Köln [A-jun] | - | Borussia Dortmund [A-jun] | 1:4 |  |
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| 5. Ronde | 16.10.2021 | Fortuna Köln [A-jun] | - | Bor. Mönchengladbach [A-jun] | 1:1 | ||||
| 6. Ronde | 24.10.2021 | VfL Bochum [A-jun] | - | Fortuna Köln [A-jun] | 1:0 | ||||
| 7. Ronde | 20.11.2021 | Fortuna Köln [A-jun] | - | Preußen Münster [A-jun] | 1:4 | |
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| 8. Ronde | 28.11.2021 | Rot-Weiss Essen [A-jun] | - | Fortuna Köln [A-jun] | 2:1 | ||||
| 10. Ronde | 05.02.2022 | SC Paderborn 07 [A-jun] | - | Fortuna Köln [A-jun] | 4:0 | ||||
| 12. Ronde | 20.02.2022 | Fortuna Köln [A-jun] | - | MSV Duisburg [A-jun] | 2:4 |  |
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| 14. Ronde | 02.04.2022 | Fortuna Köln [A-jun] | - | FC Schalke 04 [A-jun] | 0:3 | ||||
| 15. Ronde | 13.04.2022 | 1. FC Köln [A-jun] | - | Fortuna Köln [A-jun] | 2:0 | ||||
| 16. Ronde | 23.04.2022 | Fortuna Köln [A-jun] | - | Fortuna Düsseldorf [A-jun] | 2:3 | |
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| 17. Ronde | 30.04.2022 | Alemannia Aachen [A-jun] | - | Fortuna Köln [A-jun] | 1:1 |
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