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| 05.02.2022 | 11:00 | 1. FC Kaiserslautern | - | 1. FC Heidenheim 1846 | 0:2 (0:0) | |
| 11:00 | FC Ingolstadt 04 | - | SC Freiburg | 1:1 (1:1) | ||
| 11:00 | Karlsruher SC | - | Bayern München | 2:1 (0:0) | ||
| 11:00 | 1. FSV Mainz 05 | - | FC Augsburg | 5:3 (2:1) | ||
| 13:00 | 1. FC Nürnberg | - | VfB Stuttgart | 0:2 (0:1) | ||
| 13:00 | Hessen Kassel | - | Eintracht Frankfurt | 1:5 (0:2) | ||
| 14:00 | SpVgg Greuther Fürth | - | 1. FC Saarbrücken | 1:2 (0:0) | ||
| 06.02.2022 | 13:00 | Stuttgarter Kickers | - | SV Darmstadt 98 | 3:2 (1:1) | |
| 14:00 | FC-Astoria Walldorf | - | SSV Ulm 1846 | 2:2 (0:1) | ||
| 15:30 | SpVgg Unterhaching | - | Kickers Offenbach | 3:0 (2:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Nürnberg | 13 | 10 | 1 | 2 | 29:15 | 14 | 31 |
| 2 |
|
VfB Stuttgart | 12 | 9 | 2 | 1 | 36:9 | 27 | 29 |
| 3 |
|
1. FSV Mainz 05 | 13 | 8 | 1 | 4 | 41:25 | 16 | 25 |
| 4 |
|
FC Augsburg | 12 | 7 | 3 | 2 | 35:21 | 14 | 24 |
| 5 |
|
Eintracht Frankfurt | 12 | 7 | 2 | 3 | 33:16 | 17 | 23 |
| 6 |
|
SpVgg Unterhaching | 12 | 7 | 2 | 3 | 21:17 | 4 | 23 |
| 7 |
|
1899 Hoffenheim | 12 | 6 | 3 | 3 | 40:24 | 16 | 21 |
| 8 |
|
1. FC Heidenheim 1846 | 13 | 6 | 2 | 5 | 25:19 | 6 | 20 |
| 9 |
|
Bayern München | 12 | 6 | 1 | 5 | 38:19 | 19 | 19 |
| 10 |
|
Karlsruher SC | 12 | 4 | 6 | 2 | 21:17 | 4 | 18 |
| 11 |
|
FC Ingolstadt 04 | 12 | 4 | 4 | 4 | 21:19 | 2 | 16 |
| 12 |
|
SC Freiburg | 13 | 4 | 4 | 5 | 23:27 | -4 | 16 |
| 13 |
|
SV Darmstadt 98 | 13 | 4 | 4 | 5 | 16:23 | -7 | 16 |
| 14 |
|
FC-Astoria Walldorf | 12 | 3 | 6 | 3 | 22:21 | 1 | 15 |
| 15 |
|
1. FC Kaiserslautern | 12 | 5 | 0 | 7 | 25:36 | -11 | 15 |
| 16 |
|
SpVgg Greuther Fürth | 13 | 3 | 3 | 7 | 17:29 | -12 | 12 |
| 17 |
|
Stuttgarter Kickers | 12 | 3 | 2 | 7 | 19:34 | -15 | 11 |
| 18 |
|
SSV Ulm 1846 | 12 | 3 | 1 | 8 | 17:28 | -11 | 10 |
| 19 |
|
Kickers Offenbach | 13 | 3 | 1 | 9 | 16:36 | -20 | 10 |
| 20 |
|
1. FC Saarbrücken | 12 | 3 | 0 | 9 | 10:24 | -14 | 9 |
| 21 |
|
Hessen Kassel | 13 | 1 | 0 | 12 | 6:52 | -46 | 3 |
| Play-offs | |
| Degradatie |
