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| 23.04.2022 | 10:00 | SpVgg Greuther Fürth | - | 1. FSV Mainz 05 | 1:1 (0:1) | |
| 13:00 | 1. FC Nürnberg | - | Karlsruher SC | 2:0 (1:0) | ||
| 13:00 | Hessen Kassel | - | FC-Astoria Walldorf | 0:6 (0:3) | ||
| 13:00 | 1899 Hoffenheim | - | FC Ingolstadt 04 | 4:1 (1:0) | ||
| 13:00 | Eintracht Frankfurt | - | SpVgg Unterhaching | 3:2 (3:0) | ||
| 13:00 | VfB Stuttgart | - | 1. FC Kaiserslautern | 3:0 (1:0) | ||
| 13:00 | 1. FC Saarbrücken | - | Stuttgarter Kickers | 1:0 (0:0) | ||
| 13:00 | FC Augsburg | - | SV Darmstadt 98 | 4:1 (2:0) | ||
| 13:00 | Bayern München | - | 1. FC Heidenheim 1846 | 2:3 (2:1) | ||
| 13:00 | SSV Ulm 1846 | - | Kickers Offenbach | 2:1 (2:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Augsburg | 19 | 13 | 4 | 2 | 55:31 | 24 | 43 |
| 2 |
|
1. FC Nürnberg | 19 | 14 | 1 | 4 | 43:26 | 17 | 43 |
| 3 |
|
Eintracht Frankfurt | 19 | 13 | 3 | 3 | 54:24 | 30 | 42 |
| 4 |
|
VfB Stuttgart | 19 | 13 | 2 | 4 | 53:16 | 37 | 41 |
| 5 |
|
1. FSV Mainz 05 | 20 | 11 | 3 | 6 | 58:39 | 19 | 36 |
| 6 |
|
1899 Hoffenheim | 19 | 10 | 5 | 4 | 62:33 | 29 | 35 |
| 7 |
|
SpVgg Unterhaching | 19 | 9 | 3 | 7 | 32:32 | 0 | 30 |
| 8 |
|
Bayern München | 19 | 9 | 2 | 8 | 55:32 | 23 | 29 |
| 9 |
|
SV Darmstadt 98 | 19 | 8 | 5 | 6 | 28:30 | -2 | 29 |
| 10 |
|
1. FC Heidenheim 1846 | 19 | 8 | 4 | 7 | 35:29 | 6 | 28 |
| 11 |
|
SC Freiburg | 19 | 8 | 4 | 7 | 39:34 | 5 | 28 |
| 12 |
|
Karlsruher SC | 19 | 7 | 7 | 5 | 33:29 | 4 | 28 |
| 13 |
|
FC-Astoria Walldorf | 19 | 6 | 7 | 6 | 38:33 | 5 | 25 |
| 14 |
|
1. FC Kaiserslautern | 19 | 8 | 1 | 10 | 39:50 | -11 | 25 |
| 15 |
|
FC Ingolstadt 04 | 19 | 6 | 4 | 9 | 34:40 | -6 | 22 |
| 16 |
|
Stuttgarter Kickers | 19 | 6 | 2 | 11 | 33:49 | -16 | 20 |
| 17 |
|
SpVgg Greuther Fürth | 19 | 4 | 4 | 11 | 26:43 | -17 | 16 |
| 18 |
|
SSV Ulm 1846 | 19 | 5 | 1 | 13 | 26:49 | -23 | 16 |
| 19 |
|
1. FC Saarbrücken | 19 | 5 | 0 | 14 | 18:41 | -23 | 15 |
| 20 |
|
Kickers Offenbach | 19 | 4 | 2 | 13 | 21:46 | -25 | 14 |
| 21 |
|
Hessen Kassel | 19 | 1 | 0 | 18 | 7:83 | -76 | 3 |
| Play-offs | |
| Degradatie |
