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| 16.01.2009 | 20:30 | RSC Anderlecht | - | Cercle Brugge | 1:2 (1:1) | |
| 17.01.2009 | 20:00 | RAEC Mons | - | KAA Gent | 1:2 (1:1) | |
| 20:00 | Sporting Lokeren | - | SV Zulte Waregem | 2:1 (1:0) | ||
| 20:00 | Club Brugge KV | - | KV Mechelen | 3:0 (1:0) | ||
| 20:00 | Standard Luik | - | FCV Dender EH | 3:2 (2:2) | ||
| 20:00 | Excelsior Mouscron | - | AFC Tubize | 1:1 (0:1) | ||
| 20:00 | KV Kortrijk | - | KSV Roeselare | 2:1 (2:0) | ||
| 18.01.2009 | 18:00 | Sporting Charleroi | - | KVC Westerlo | 1:2 (0:1) | |
| 20:30 | Germinal Beerschot | - | KRC Genk | 4:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 18 | 12 | 2 | 4 | 44:19 | 25 | 38 |
| 2 |
|
Standard Luik | 18 | 11 | 4 | 3 | 33:19 | 14 | 37 |
| 3 |
|
Club Brugge KV | 18 | 10 | 4 | 4 | 32:23 | 9 | 34 |
| 4 |
|
KVC Westerlo | 18 | 9 | 4 | 5 | 24:21 | 3 | 31 |
| 5 |
|
Cercle Brugge | 18 | 10 | 1 | 7 | 31:29 | 2 | 31 |
| 6 |
|
Sporting Lokeren | 18 | 7 | 9 | 2 | 24:15 | 9 | 30 |
| 7 |
|
KRC Genk | 18 | 9 | 3 | 6 | 27:26 | 1 | 30 |
| 8 |
|
Excelsior Mouscron | 18 | 8 | 4 | 6 | 29:23 | 6 | 28 |
| 9 |
|
KAA Gent | 18 | 7 | 5 | 6 | 35:25 | 10 | 26 |
| 10 |
|
KV Kortrijk | 18 | 6 | 7 | 5 | 20:25 | -5 | 25 |
| 11 |
|
SV Zulte Waregem | 18 | 7 | 3 | 8 | 26:25 | 1 | 24 |
| 12 |
|
Sporting Charleroi | 18 | 6 | 3 | 9 | 23:28 | -5 | 21 |
| 13 |
|
Germinal Beerschot | 18 | 4 | 6 | 8 | 22:24 | -2 | 18 |
| 14 |
|
KV Mechelen | 18 | 4 | 6 | 8 | 19:31 | -12 | 18 |
| 15 |
|
RAEC Mons | 18 | 3 | 6 | 9 | 20:26 | -6 | 15 |
| 16 |
|
FCV Dender EH | 18 | 3 | 6 | 9 | 23:36 | -13 | 15 |
| 17 |
|
AFC Tubize | 18 | 4 | 3 | 11 | 21:37 | -16 | 15 |
| 18 |
|
KSV Roeselare | 18 | 2 | 4 | 12 | 14:35 | -21 | 10 |
| Champions League Kwali. | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
