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| U | Real Hope | - | Cruz Azul | 0:2 (0:1) | ||
| R | Cruz Azul | - | Real Hope | 5:0 (3:0) | ||
| U: 05.02.2025 02:00 | R: 12.02.2025 04:00 | Winnaars: Cruz Azul | ||||
| U | Forge FC | - | CF Monterrey | 0:2 (0:0) | ||
| R | CF Monterrey | - | Forge FC | 3:0 (1:0) | ||
| U: 06.02.2025 02:00 | R: 12.02.2025 02:00 | Winnaars: CF Monterrey | ||||
| U | Real Estelí FC | - | UANL Tigres | 1:0 (0:0) | ||
| R | UANL Tigres | - | Real Estelí FC | 3:0 (2:0) | ||
| U: 06.02.2025 04:00 | R: 13.02.2025 04:00 | Winnaars: UANL Tigres | ||||
| U | Cibao FC | - | Deportivo Guadalajara | 1:1 (1:0) | ||
| R | Deportivo Guadalajara | - | Cibao FC | 3:0 (1:0) | ||
| U: 07.02.2025 02:00 | R: 13.02.2025 02:00 | Winnaars: Deportivo Guadalajara | ||||
| U | Cavalry FC | - | Pumas UNAM | 2:1 (0:1) | ||
| R | Pumas UNAM | - | Cavalry FC | 2:0 (0:0) | ||
| U: 07.02.2025 04:00 | R: 14.02.2025 02:00 | Winnaars: Pumas UNAM | ||||
| U | Colorado Rapids | - | Los Angeles FC | 2:1 (0:0) | ||
| R | Los Angeles FC | - | Colorado Rapids | 1:0 (0:0) | ||
| U: 19.02.2025 04:00 | R: 26.02.2025 04:00 | Winnaars: Los Angeles FC | ||||
| U | CS Herediano | - | Real Salt Lake | 0:0 (0:0) | ||
| R | Real Salt Lake | - | CS Herediano | 1:2 (1:0) | ||
| U: 20.02.2025 00:30 | R: 27.02.2025 02:30 | Winnaars: CS Herediano | ||||
| U | Sporting Kansas City | - | Inter Miami CF | 0:1 (0:0) | ||
| R | Inter Miami CF | - | Sporting Kansas City | 3:1 (3:0) | ||
| U: 20.02.2025 02:00 | R: 26.02.2025 02:00 | Winnaars: Inter Miami CF | ||||
| U | Antigua GFC | - | Seattle Sounders | 1:3 (1:1) | ||
| R | Seattle Sounders | - | Antigua GFC | 3:1 (1:1) | ||
| U: 20.02.2025 02:00 | R: 27.02.2025 04:30 | Winnaars: Seattle Sounders | ||||
| U | Motagua | - | FC Cincinnati | 1:4 (1:1) | ||
| R | FC Cincinnati | - | Motagua | 1:1 (1:1) | ||
| U: 20.02.2025 04:00 | R: 27.02.2025 00:30 | Winnaars: FC Cincinnati | ||||
| U | Deportivo Saprissa | - | Vancouver Whitecaps | 2:1 (0:1) | ||
| R | Vancouver Whitecaps | - | Deportivo Saprissa | 2:0 (0:0) | ||
| U: 21.02.2025 02:00 | R: 28.02.2025 04:00 | Winnaars: Vancouver Whitecaps | ||||
