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| U | AZ Alkmaar | - | Valencia CF | 2:1 (1:0) | ||
| R | Valencia CF | - | AZ Alkmaar | 4:0 (2:0) | ||
| U: 29.03.2012 21:05 | R: 05.04.2012 21:05 | Winnaars: Valencia CF | ||||
| U | FC Schalke 04 | - | Athletic Club | 2:4 (1:1) | ||
| R | Athletic Club | - | FC Schalke 04 | 2:2 (1:1) | ||
| U: 29.03.2012 21:05 | R: 05.04.2012 21:05 | Winnaars: Athletic Club | ||||
| U | Sporting CP | - | Metalist Kharkiv | 2:1 (0:0) | ||
| R | Metalist Kharkiv | - | Sporting CP | 1:1 (0:1) | ||
| U: 29.03.2012 21:05 | R: 05.04.2012 21:05 | Winnaars: Sporting CP | ||||
| U | Atlético Madrid | - | Hannover 96 | 2:1 (1:1) | ||
| R | Hannover 96 | - | Atlético Madrid | 1:2 (0:0) | ||
| U: 29.03.2012 21:05 | R: 05.04.2012 21:05 | Winnaars: Atlético Madrid | ||||
