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| U | Fenerbahçe | - | RSC Anderlecht | 3:0 (2:0) | ||
| R | RSC Anderlecht | - | Fenerbahçe | 2:2 (1:1) | ||
| U: 13.02.2025 18:45 | R: 20.02.2025 21:00 | Winnaars: Fenerbahçe | ||||
| U | Union Saint-Gilloise | - | AFC Ajax | 0:2 (0:0) | ||
| R | AFC Ajax | - | Union Saint-Gilloise | 1:2 (0:2, 0:2) n.v. | ||
| U: 13.02.2025 18:45 | R: 20.02.2025 21:00 | Winnaars: AFC Ajax | ||||
| U | FC Midtjylland | - | Real Sociedad | 1:2 (1:2) | ||
| R | Real Sociedad | - | FC Midtjylland | 5:2 (3:2) | ||
| U: 13.02.2025 18:45 | R: 20.02.2025 21:00 | Winnaars: Real Sociedad | ||||
| U | Ferencvárosi TC | - | Viktoria Plzeň | 1:0 (1:0) | ||
| R | Viktoria Plzeň | - | Ferencvárosi TC | 3:0 (3:0) | ||
| U: 13.02.2025 18:45 | R: 20.02.2025 21:00 | Winnaars: Viktoria Plzeň | ||||
| U | FC Twente | - | FK Bodø/Glimt | 2:1 (1:0) | ||
| R | FK Bodø/Glimt | - | FC Twente | 5:2 (0:1, 3:2) n.v. | ||
| U: 13.02.2025 21:00 | R: 20.02.2025 18:45 | Winnaars: FK Bodø/Glimt | ||||
| U | PAOK Saloniki | - | FCSB | 1:2 (1:0) | ||
| R | FCSB | - | PAOK Saloniki | 2:0 (1:0) | ||
| U: 13.02.2025 21:00 | R: 20.02.2025 18:45 | Winnaars: FCSB | ||||
| U | AZ Alkmaar | - | Galatasaray | 4:1 (2:1) | ||
| R | Galatasaray | - | AZ Alkmaar | 2:2 (0:1) | ||
| U: 13.02.2025 21:00 | R: 20.02.2025 18:45 | Winnaars: AZ Alkmaar | ||||
| U | FC Porto | - | AS Roma | 1:1 (0:1) | ||
| R | AS Roma | - | FC Porto | 3:2 (2:1) | ||
| U: 13.02.2025 21:00 | R: 20.02.2025 18:45 | Winnaars: AS Roma | ||||
