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| 01.10.2022 | 16:00 | CF Pachuca | - | Pumas UNAM | 3:3 (2:0) | |
| 17:00 | Mazatlán FC | - | Santos Laguna | 2:3 (1:1) | ||
| 19:15 | FC Juárez | - | Club Necaxa | 2:2 (1:2) | ||
| 19:30 | Puebla FC | - | Gallos Blancos | 2:2 (1:1) | ||
| 19:45 | CF América | - | Deportivo Toluca | 2:1 (1:0) | ||
| 23:00 | CF Monterrey | - | UANL Tigres | 2:2 (1:1) | ||
| 02.10.2022 | 16:45 | Atlético San Luis | - | Atlas Guadalajara | 0:3 (0:1) | |
| 12.10.2022 | 21:45 | Club Tijuana | - | Club León | 5:1 (3:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 13 | 10 | 2 | 1 | 31:15 | 16 | 32 |
| 2 |
|
CF Pachuca | 14 | 5 | 7 | 2 | 22:14 | 8 | 22 |
| 3 |
|
Club Necaxa | 13 | 6 | 3 | 4 | 21:9 | 12 | 21 |
| 4 |
|
Deportivo Toluca | 13 | 6 | 3 | 4 | 26:19 | 7 | 21 |
| 5 |
|
CF América | 13 | 6 | 3 | 4 | 25:20 | 5 | 21 |
| 6 |
|
Cruz Azul | 13 | 4 | 4 | 5 | 24:25 | -1 | 16 |
| 7 |
|
Gallos Blancos | 14 | 3 | 4 | 7 | 18:21 | -3 | 13 |
| 8 |
|
FC Juárez | 14 | 3 | 1 | 10 | 17:50 | -33 | 10 |
| 9 |
|
Puebla FC | 13 | 2 | 3 | 8 | 16:27 | -11 | 9 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 13 | 9 | 2 | 2 | 39:14 | 25 | 29 |
| 2 |
|
Deportivo Guadalajara | 13 | 8 | 1 | 4 | 27:16 | 11 | 25 |
| 3 |
|
CF Monterrey | 13 | 6 | 6 | 1 | 33:19 | 14 | 24 |
| 4 |
|
Atlas Guadalajara | 13 | 6 | 3 | 4 | 28:18 | 10 | 21 |
| 5 |
|
Santos Laguna | 13 | 6 | 3 | 4 | 30:21 | 9 | 21 |
| 6 |
|
UANL Tigres | 13 | 6 | 3 | 4 | 24:24 | 0 | 21 |
| 7 |
|
Club León | 14 | 6 | 2 | 6 | 25:20 | 5 | 20 |
| 8 |
|
Atlético San Luis | 14 | 2 | 0 | 12 | 15:56 | -41 | 6 |
| 9 |
|
Mazatlán FC | 14 | 1 | 0 | 13 | 14:47 | -33 | 3 |
| Play-offs | |
| Play-offs |
