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| 17.03.2006 | 20:00 | FC Volendam | - | FC Emmen | 5:2 (3:2) | |
| 20:00 | BV Veendam | - | Fortuna Sittard | 2:2 (1:0) | ||
| 20:00 | FC Den Bosch | - | Stormvogels Telstar | 1:1 (1:0) | ||
| 20:00 | SBV Excelsior | - | Go Ahead Eagles | 2:1 (1:1) | ||
| 20:00 | FC Dordrecht | - | SC Cambuur | 1:2 (1:0) | ||
| 20:00 | FC Eindhoven | - | VVV-Venlo | 1:3 (0:2) | ||
| 20:00 | De Graafschap | - | Helmond Sport | 2:2 (2:0) | ||
| 20:00 | MVV Maastricht | - | FC Omniworld | 2:2 (1:1) | ||
| 20:00 | HFC Haarlem | - | TOP Oss | 1:2 (1:0) | ||
| 20:00 | FC Zwolle | - | AGOVV | 1:3 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 35 | 20 | 8 | 7 | 63:23 | 40 | 68 |
| 2 |
|
VVV-Venlo | 35 | 18 | 8 | 9 | 48:31 | 17 | 62 |
| 3 |
|
FC Volendam | 35 | 17 | 9 | 9 | 53:38 | 15 | 60 |
| 4 |
|
Helmond Sport | 35 | 17 | 7 | 11 | 56:51 | 5 | 58 |
| 5 |
|
FC Emmen | 35 | 17 | 6 | 12 | 63:48 | 15 | 57 |
| 6 |
|
FC Den Bosch | 35 | 15 | 11 | 9 | 58:48 | 10 | 56 |
| 7 |
|
De Graafschap | 35 | 15 | 10 | 10 | 55:46 | 9 | 55 |
| 8 |
|
HFC Haarlem | 35 | 16 | 7 | 12 | 56:50 | 6 | 55 |
| 9 |
|
AGOVV | 35 | 16 | 5 | 14 | 61:57 | 4 | 53 |
| 10 |
|
TOP Oss | 35 | 14 | 10 | 11 | 47:48 | -1 | 52 |
| 11 |
|
FC Zwolle | 35 | 14 | 9 | 12 | 54:47 | 7 | 51 |
| 12 |
|
FC Dordrecht | 35 | 13 | 11 | 11 | 52:39 | 13 | 50 |
| 13 |
|
MVV Maastricht | 35 | 12 | 11 | 12 | 50:49 | 1 | 47 |
| 14 |
|
BV Veendam | 35 | 12 | 9 | 14 | 49:56 | -7 | 45 |
| 15 |
|
SC Cambuur | 35 | 10 | 13 | 12 | 40:46 | -6 | 40 |
| 16 |
|
Stormvogels Telstar | 35 | 8 | 13 | 14 | 33:49 | -16 | 37 |
| 17 |
|
FC Eindhoven | 35 | 10 | 5 | 20 | 47:58 | -11 | 35 |
| 18 |
|
Go Ahead Eagles | 35 | 7 | 11 | 17 | 42:64 | -22 | 32 |
| 19 |
|
FC Omniworld | 35 | 7 | 7 | 21 | 45:78 | -33 | 28 |
| 20 |
|
Fortuna Sittard | 35 | 2 | 10 | 23 | 32:78 | -46 | 16 |
| Promotie |
